- Skizoril 100 mg Tablet effectively treats treatment-resistant schizophrenia in adults.
- This medication reduces the risk of suicidal behavior in patients with schizophrenia or schizoaffective disorder.
- Skizoril 100 mg Tablet improves symptoms in up to 60% of patients who did not respond to other medications.
- It stabilizes complex neurochemistry, allowing patients to transition from institutional care to independent living.
- Skizoril 100 mg Tablet is less likely to cause extrapyramidal side effects compared to other antipsychotics.
- This formulation allows for gradual titration, helping doctors build up to a therapeutic dose while monitoring side effects.
- Skizoril 100 mg Tablet can improve negative symptoms of schizophrenia, such as emotional withdrawal and lack of motivation.
- Patients using Skizoril 100 mg Tablet benefit from its unique pharmacological profile that targets multiple neurotransmitter systems.
- The medication is particularly advantageous for those who experience significant sedation with other treatments.
- Skizoril 100 mg Tablet provides a controlled approach to managing severe psychiatric symptoms.
- This therapy is often introduced when other treatments have proven insufficient, ensuring comprehensive care.
- Skizoril 100 mg Tablet supports long-term management strategies for chronic psychiatric conditions.
Skizoril 100 mg Tablet - Strip of 10
Prescription Required
Compositions : Clozapine 100mg
₹74.56
(Incl. GST)
MRP :
(Incl. GST)
MRP :
In stock
Delivery within 2 to 7 Working Days
Manufacture/Marketer: Intas Pharmaceuticals Ltd.
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Quick and Secure
No Hidden Charges
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18K Pincodes Served
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Description
Skizoril 100 mg Tablet is an oral antipsychotic medication that contains Clozapine as its active ingredient. This formulation is widely recognized as the 'gold standard' for treating treatment-resistant schizophrenia, making it a crucial option for patients who have not responded adequately to other antipsychotic medications. Skizoril 100 mg Tablet is also indicated for reducing the risk of recurrent suicidal behavior in individuals diagnosed with schizophrenia or schizoaffective disorder. The primary purpose of Skizoril 100 mg Tablet is to provide effective management of severe psychiatric conditions, particularly in cases where traditional therapies have failed. The therapeutic category of Skizoril 100 mg Tablet falls under atypical antipsychotics, which are known for their unique pharmacological profiles and mechanisms of action. Each Skizoril 100 mg Tablet contains Clozapine, which distinguishes it from standard antipsychotics that primarily target dopamine D2 receptors. Instead, Clozapine exhibits a low affinity for D2 receptors while showing a significantly higher affinity for D4 receptors, serotonin (5-HT2A), adrenergic (alpha1 and alpha2), cholinergic (M1), and histaminergic (H1) receptors. This broad-spectrum receptor profile is believed to contribute to the superior efficacy of Skizoril 100 mg Tablet in patients who have not achieved symptom relief with other treatments. Furthermore, the unique action of Skizoril 100 mg Tablet helps minimize the risk of movement-related side effects commonly associated with other antipsychotic medications, such as Parkinsonism. In summary, Skizoril 100 mg Tablet represents a critical therapeutic option for individuals whose conditions have proven refractory to first- and second-generation antipsychotics, offering hope and improved quality of life for many patients.
Product Details
Uses & Benefits
How Skizoril 100 mg Tablet works
- Clozapine in Skizoril 100 mg Tablet works through broad-spectrum neuro-modulation, targeting various neurotransmitter receptors.
- Dopamine D4 blockade reduces psychotic symptoms without affecting motor control.
- Serotonin 5-HT2A antagonism improves mood and cognition while preventing tremors.
- Rapid dissociation from D2 receptors minimizes the risk of muscle stiffness.
- Adrenergic and histamine interactions contribute to common side effects like sleepiness and low blood pressure.
- Glutamatergic modulation enhances NMDA receptor function, improving cognitive and negative symptoms.
How to use Skizoril 100 mg Tablet
- Skizoril 100 mg Tablet should be taken once or twice daily, with the larger portion often taken at bedtime to manage sedation.
- The tablet must be swallowed whole with water and can be taken with or without food.
- Mandatory blood tests are required; if a test is missed, the doctor cannot prescribe more medication.
- Consistency in timing is crucial; take Skizoril 100 mg Tablet at the same time every day.
- If doses are missed for more than 48 hours, a complete restart from a low dose is necessary.
- Your doctor will initiate treatment with a very low dose (e.g., 12.5mg or 25mg) before gradually increasing to Skizoril 100 mg Tablet.
- Compliance with prescribed dosages is essential; do not change brands without consulting your doctor.
- The maximum dose typically does not exceed 900mg per day, depending on individual tolerance and blood levels.
Lifestyle Advice
- Maintain a high-fiber diet and drink plenty of water to prevent constipation while on Skizoril 100 mg Tablet.
- Monitor your weight regularly and engage in physical activity to mitigate weight gain associated with this medication.
- Stay hydrated by drinking at least two liters of water daily to support kidney function and overall health.
- Be cautious when changing positions; rise slowly from sitting or lying down to avoid dizziness.
- Report any fever or sore throat immediately as these may indicate a drop in white blood cell count.
Safety Advice
Side Effects
Side Effects
- Common side effects of Skizoril 100 mg Tablet include excessive drooling (sialorrhea), significant drowsiness, and increased heart rate (tachycardia).
- Weight gain is frequently reported due to increased appetite and metabolic changes associated with Skizoril 100 mg Tablet.
- Constipation can become severe if not managed early; dietary adjustments may be necessary.
- Dizziness may occur, especially when standing up quickly; rise slowly to avoid fainting.
- Serious side effects requiring immediate medical attention include agranulocytosis, myocarditis, seizures, severe constipation, and hyperglycemia.
- Patients should monitor for signs of infection such as fever or sore throat while on Skizoril 100 mg Tablet due to the risk of low white blood cell count.
Precautions and Warnings
Precautions & Warnings
- Patients with a history of agranulocytosis should avoid using Skizoril 100 mg Tablet due to potential risks.
- Consultation with a healthcare provider is essential before using this medication during pregnancy or breastfeeding.
- Avoid alcohol consumption while taking Skizoril 100 mg Tablet as it can enhance sedative effects and respiratory risks.
- Driving or operating machinery should be avoided during the initial weeks of treatment due to sedation risks.
- Regular blood tests are mandatory to monitor white blood cell counts during treatment with Skizoril 100 mg Tablet.
- Patients should inform their doctor about any existing medical conditions such as heart disease or diabetes before starting therapy.
FAQs
1. Why are frequent blood tests necessary?
Frequent blood tests are essential to monitor for agranulocytosis, a rare but serious condition that can lead to a dangerous drop in white blood cells.
2. Is weight gain a common side effect?
Yes, weight gain is commonly observed due to increased appetite and metabolic changes associated with Skizoril 100 mg Tablet.
3. What causes excessive drooling at night?
Excessive drooling may occur because Clozapine can overstimulate salivary glands or affect swallowing during sleep.
4. Can I stop taking Skizoril 100 mg Tablet if I feel better?
No, abruptly stopping Skizoril 100 mg Tablet can lead to severe relapses of psychosis or withdrawal symptoms.
5. Why is constipation considered serious?
Constipation can become severe on Clozapine, potentially leading to life-threatening bowel obstructions if not managed properly.
6. Does smoking affect the medication?
Yes, tobacco smoke can lower Clozapine levels in the blood; quitting smoking may require dosage adjustments.
7. Is Skizoril 100 mg Tablet safe for sleep issues?
No, Skizoril 100 mg Tablet is not intended for use as a simple sedative due to its potent antipsychotic properties.
Frequent blood tests are essential to monitor for agranulocytosis, a rare but serious condition that can lead to a dangerous drop in white blood cells.
2. Is weight gain a common side effect?
Yes, weight gain is commonly observed due to increased appetite and metabolic changes associated with Skizoril 100 mg Tablet.
3. What causes excessive drooling at night?
Excessive drooling may occur because Clozapine can overstimulate salivary glands or affect swallowing during sleep.
4. Can I stop taking Skizoril 100 mg Tablet if I feel better?
No, abruptly stopping Skizoril 100 mg Tablet can lead to severe relapses of psychosis or withdrawal symptoms.
5. Why is constipation considered serious?
Constipation can become severe on Clozapine, potentially leading to life-threatening bowel obstructions if not managed properly.
6. Does smoking affect the medication?
Yes, tobacco smoke can lower Clozapine levels in the blood; quitting smoking may require dosage adjustments.
7. Is Skizoril 100 mg Tablet safe for sleep issues?
No, Skizoril 100 mg Tablet is not intended for use as a simple sedative due to its potent antipsychotic properties.
Instructions
Directions for Use
Use only as prescribed by your physician.
Storage and Disposal
Please refer to the product label for storage information.
More Information
| SKU | 145117 |
|---|---|
| Country of Manufacture | India |
| Manufacturer Address | Intas Pharmaceuticals Ltd. |
| Return/Buy Back policy | Non-returnable |
| Prescription Required | Yes |
| Storage | Please refer to the product label for storage information. |
| Seller | Kogland Commerce Pvt Ltd (TN) |
Skizoril 100 mg Tablet is an oral antipsychotic medication that contains Clozapine as its active ingredient. This formulation is widely recognized as the 'gold standard' for treating treatment-resistant schizophrenia, making it a crucial option for patients who have not responded adequately to other antipsychotic medications. Skizoril 100 mg Tablet is also indicated for reducing the risk of recurrent suicidal behavior in individuals diagnosed with schizophrenia or schizoaffective disorder. The primary purpose of Skizoril 100 mg Tablet is to provide effective management of severe psychiatric conditions, particularly in cases where traditional therapies have failed. The therapeutic category of Skizoril 100 mg Tablet falls under atypical antipsychotics, which are known for their unique pharmacological profiles and mechanisms of action. Each Skizoril 100 mg Tablet contains Clozapine, which distinguishes it from standard antipsychotics that primarily target dopamine D2 receptors. Instead, Clozapine exhibits a low affinity for D2 receptors while showing a significantly higher affinity for D4 receptors, serotonin (5-HT2A), adrenergic (alpha1 and alpha2), cholinergic (M1), and histaminergic (H1) receptors. This broad-spectrum receptor profile is believed to contribute to the superior efficacy of Skizoril 100 mg Tablet in patients who have not achieved symptom relief with other treatments. Furthermore, the unique action of Skizoril 100 mg Tablet helps minimize the risk of movement-related side effects commonly associated with other antipsychotic medications, such as Parkinsonism. In summary, Skizoril 100 mg Tablet represents a critical therapeutic option for individuals whose conditions have proven refractory to first- and second-generation antipsychotics, offering hope and improved quality of life for many patients.
Uses & Benefits
- Skizoril 100 mg Tablet effectively treats treatment-resistant schizophrenia in adults.
- This medication reduces the risk of suicidal behavior in patients with schizophrenia or schizoaffective disorder.
- Skizoril 100 mg Tablet improves symptoms in up to 60% of patients who did not respond to other medications.
- It stabilizes complex neurochemistry, allowing patients to transition from institutional care to independent living.
- Skizoril 100 mg Tablet is less likely to cause extrapyramidal side effects compared to other antipsychotics.
- This formulation allows for gradual titration, helping doctors build up to a therapeutic dose while monitoring side effects.
- Skizoril 100 mg Tablet can improve negative symptoms of schizophrenia, such as emotional withdrawal and lack of motivation.
- Patients using Skizoril 100 mg Tablet benefit from its unique pharmacological profile that targets multiple neurotransmitter systems.
- The medication is particularly advantageous for those who experience significant sedation with other treatments.
- Skizoril 100 mg Tablet provides a controlled approach to managing severe psychiatric symptoms.
- This therapy is often introduced when other treatments have proven insufficient, ensuring comprehensive care.
- Skizoril 100 mg Tablet supports long-term management strategies for chronic psychiatric conditions.
How Skizoril 100 mg Tablet works
- Clozapine in Skizoril 100 mg Tablet works through broad-spectrum neuro-modulation, targeting various neurotransmitter receptors.
- Dopamine D4 blockade reduces psychotic symptoms without affecting motor control.
- Serotonin 5-HT2A antagonism improves mood and cognition while preventing tremors.
- Rapid dissociation from D2 receptors minimizes the risk of muscle stiffness.
- Adrenergic and histamine interactions contribute to common side effects like sleepiness and low blood pressure.
- Glutamatergic modulation enhances NMDA receptor function, improving cognitive and negative symptoms.
How to use Skizoril 100 mg Tablet
- Skizoril 100 mg Tablet should be taken once or twice daily, with the larger portion often taken at bedtime to manage sedation.
- The tablet must be swallowed whole with water and can be taken with or without food.
- Mandatory blood tests are required; if a test is missed, the doctor cannot prescribe more medication.
- Consistency in timing is crucial; take Skizoril 100 mg Tablet at the same time every day.
- If doses are missed for more than 48 hours, a complete restart from a low dose is necessary.
- Your doctor will initiate treatment with a very low dose (e.g., 12.5mg or 25mg) before gradually increasing to Skizoril 100 mg Tablet.
- Compliance with prescribed dosages is essential; do not change brands without consulting your doctor.
- The maximum dose typically does not exceed 900mg per day, depending on individual tolerance and blood levels.
Lifestyle Advice
- Maintain a high-fiber diet and drink plenty of water to prevent constipation while on Skizoril 100 mg Tablet.
- Monitor your weight regularly and engage in physical activity to mitigate weight gain associated with this medication.
- Stay hydrated by drinking at least two liters of water daily to support kidney function and overall health.
- Be cautious when changing positions; rise slowly from sitting or lying down to avoid dizziness.
- Report any fever or sore throat immediately as these may indicate a drop in white blood cell count.
Side Effects
Side Effects
- Common side effects of Skizoril 100 mg Tablet include excessive drooling (sialorrhea), significant drowsiness, and increased heart rate (tachycardia).
- Weight gain is frequently reported due to increased appetite and metabolic changes associated with Skizoril 100 mg Tablet.
- Constipation can become severe if not managed early; dietary adjustments may be necessary.
- Dizziness may occur, especially when standing up quickly; rise slowly to avoid fainting.
- Serious side effects requiring immediate medical attention include agranulocytosis, myocarditis, seizures, severe constipation, and hyperglycemia.
- Patients should monitor for signs of infection such as fever or sore throat while on Skizoril 100 mg Tablet due to the risk of low white blood cell count.
Precautions and Warnings
Precautions & Warnings
- Patients with a history of agranulocytosis should avoid using Skizoril 100 mg Tablet due to potential risks.
- Consultation with a healthcare provider is essential before using this medication during pregnancy or breastfeeding.
- Avoid alcohol consumption while taking Skizoril 100 mg Tablet as it can enhance sedative effects and respiratory risks.
- Driving or operating machinery should be avoided during the initial weeks of treatment due to sedation risks.
- Regular blood tests are mandatory to monitor white blood cell counts during treatment with Skizoril 100 mg Tablet.
- Patients should inform their doctor about any existing medical conditions such as heart disease or diabetes before starting therapy.
1. Why are frequent blood tests necessary?
Frequent blood tests are essential to monitor for agranulocytosis, a rare but serious condition that can lead to a dangerous drop in white blood cells.
2. Is weight gain a common side effect?
Yes, weight gain is commonly observed due to increased appetite and metabolic changes associated with Skizoril 100 mg Tablet.
3. What causes excessive drooling at night?
Excessive drooling may occur because Clozapine can overstimulate salivary glands or affect swallowing during sleep.
4. Can I stop taking Skizoril 100 mg Tablet if I feel better?
No, abruptly stopping Skizoril 100 mg Tablet can lead to severe relapses of psychosis or withdrawal symptoms.
5. Why is constipation considered serious?
Constipation can become severe on Clozapine, potentially leading to life-threatening bowel obstructions if not managed properly.
6. Does smoking affect the medication?
Yes, tobacco smoke can lower Clozapine levels in the blood; quitting smoking may require dosage adjustments.
7. Is Skizoril 100 mg Tablet safe for sleep issues?
No, Skizoril 100 mg Tablet is not intended for use as a simple sedative due to its potent antipsychotic properties.
Frequent blood tests are essential to monitor for agranulocytosis, a rare but serious condition that can lead to a dangerous drop in white blood cells.
2. Is weight gain a common side effect?
Yes, weight gain is commonly observed due to increased appetite and metabolic changes associated with Skizoril 100 mg Tablet.
3. What causes excessive drooling at night?
Excessive drooling may occur because Clozapine can overstimulate salivary glands or affect swallowing during sleep.
4. Can I stop taking Skizoril 100 mg Tablet if I feel better?
No, abruptly stopping Skizoril 100 mg Tablet can lead to severe relapses of psychosis or withdrawal symptoms.
5. Why is constipation considered serious?
Constipation can become severe on Clozapine, potentially leading to life-threatening bowel obstructions if not managed properly.
6. Does smoking affect the medication?
Yes, tobacco smoke can lower Clozapine levels in the blood; quitting smoking may require dosage adjustments.
7. Is Skizoril 100 mg Tablet safe for sleep issues?
No, Skizoril 100 mg Tablet is not intended for use as a simple sedative due to its potent antipsychotic properties.
Directions for Use
Use only as prescribed by your physician.
Storage and Disposal
Please refer to the product label for storage information.
| SKU | 145117 |
|---|---|
| Country of Manufacture | India |
| Manufacturer Address | Intas Pharmaceuticals Ltd. |
| Return/Buy Back policy | Non-returnable |
| Prescription Required | Yes |
| Storage | Please refer to the product label for storage information. |
| Seller | Kogland Commerce Pvt Ltd (TN) |
Door Step Delivery
Quick and Secure
No Hidden Charges
Pay only what's shown
18K Pincodes Served
With Trust & Reliability
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