ATZ 50 mg Tablet is a prescription-only cytotoxic immunosuppressant that plays a crucial role in long-term immune modulation. Composed primarily of Azathioprine, ATZ 50 mg Tablet serves as a prodrug, which means it is converted within the body into its active metabolites. This transformation is essential for its therapeutic effects. Each ATZ 50 mg Tablet contains Azathioprine, which functions as a purine antimetabolite. Upon ingestion, ATZ 50 mg Tablet is metabolized into 6-mercaptopurine (6-MP) and subsequently into thio-guanine nucleotides. These active compounds interfere with the synthesis of DNA and RNA in rapidly dividing cells, particularly T and B lymphocytes. By disrupting the genetic blueprints of these immune cells, ATZ 50 mg Tablet effectively reduces the immune response that could otherwise attack a transplanted organ or the body's own healthy cells. The primary purpose of ATZ 50 mg Tablet lies in its ability to prevent organ rejection in transplant patients and to manage autoimmune disorders. It is categorized under immunosuppressants, making it a vital component in the treatment of conditions such as severe rheumatoid arthritis, ulcerative colitis, Crohn's disease, and autoimmune hepatitis. The therapeutic category of ATZ 50 mg Tablet highlights its importance in managing complex immune-mediated conditions, ensuring that patients receive effective treatment while minimizing the risk of complications associated with their underlying diseases. Overall, ATZ 50 mg Tablet is an essential medication for individuals requiring long-term immune suppression, providing both safety and efficacy in its use.
Uses & Benefits
ATZ 50 mg Tablet effectively prevents organ rejection in kidney, heart, and liver transplant patients.
This formulation is indicated for severe rheumatoid arthritis that has not responded to other treatments.
ATZ 50 mg Tablet is beneficial in managing chronic inflammatory conditions like ulcerative colitis and Crohn's disease.
It offers a steroid-sparing effect, allowing patients to reduce corticosteroid doses and avoid long-term side effects.
ATZ 50 mg Tablet helps protect vital organs from damage caused by chronic inflammation.
This medication has an established safety profile due to decades of clinical use.
ATZ 50 mg Tablet can lead to long periods of disease remission for patients with autoimmune disorders.
It serves as a secondary line of defense for patients who have failed first-line therapies.
ATZ 50 mg Tablet is essential for preventing complications associated with mineral deficiencies in patients undergoing treatment.
This therapy is particularly useful for patients requiring lifetime management of their conditions.
ATZ 50 mg Tablet can significantly improve the quality of life for individuals with chronic immune-mediated diseases.
The medication's ability to selectively target pathways involved in lymphocyte proliferation makes it a valuable treatment option.
How ATZ 50 mg Tablet works
ATZ 50 mg Tablet functions as an immunosuppressant that reduces the action of the body's immune system. This action prevents the rejection of transplanted organs and blocks certain chemical messengers responsible for inflammation associated with joint diseases.
By inhibiting lymphocyte proliferation, ATZ 50 mg Tablet dampens the overactive immune response.
The active metabolites of Azathioprine interfere with DNA and RNA synthesis in immune cells.
ATZ 50 mg Tablet selectively targets T and B lymphocytes, which are crucial in mediating immune responses.
This mechanism helps maintain a balance in immune function without completely shutting down the body's defenses.
ATZ 50 mg Tablet is particularly effective in managing autoimmune disorders by modulating immune activity.
How to use ATZ 50 mg Tablet
ATZ 50 mg Tablet should be taken once or twice daily as prescribed by your healthcare provider.
Swallow the tablet whole; do not crush or break it to avoid exposure to cytotoxic substances.
It is recommended to take ATZ 50 mg Tablet after meals to minimize nausea and stomach upset.
Consistency is key; take ATZ 50 mg Tablet at the same time every day to maintain stable drug levels in the body.
For transplant patients, the initial dose typically ranges from 3mg to 5mg per kg of body weight daily, adjusted based on blood test results.
For autoimmune conditions, dosing often starts at 1mg to 3mg per kg of body weight.
The maintenance dose for most adults usually equates to between 50mg to 150mg daily.
Consult your doctor for any necessary dose adjustments based on your individual response and lab results.
Lifestyle Advice
Maintain a balanced diet rich in vitamins and minerals to support overall health while taking ATZ 50 mg Tablet.
Avoid excessive sun exposure; use sunscreen and protective clothing when outdoors to prevent skin damage.
Stay hydrated and maintain regular physical activity as tolerated to enhance well-being during treatment.
Monitor for signs of infection and report any symptoms promptly to your healthcare provider.
Adhere strictly to scheduled blood tests to ensure safe monitoring of your health status while on ATZ 50 mg Tablet.
Side Effects
Side Effects
Common side effects include nausea and vomiting, especially during the initial weeks of treatment.
Loss of appetite may occur as a side effect of ATZ 50 mg Tablet.
Increased sensitivity to sunlight can lead to sunburn; protective measures are advised.
Some patients may experience mild hair thinning while on ATZ 50 mg Tablet.
Uncommon side effects may include gastrointestinal discomfort such as diarrhea or stomach pain.
Joint pain or muscle aches can occur occasionally during treatment with ATZ 50 mg Tablet.
Mouth ulcers may develop as a side effect; consult your doctor if they persist.
Serious side effects requiring immediate medical attention include bone marrow suppression, indicated by unusual bruising or extreme fatigue.
Signs of infection such as fever or persistent cough should be reported to a healthcare provider promptly.
Liver damage symptoms like jaundice or dark urine necessitate urgent medical evaluation.
Precautions and Warnings
Precautions & Warnings
ATZ 50 mg Tablet should not be used by individuals with known hypersensitivity to Azathioprine or its components.
Caution is advised for patients with kidney or liver disease; dose adjustments may be necessary.
Pregnant women should avoid using ATZ 50 mg Tablet due to potential fetal harm; consult your doctor if pregnancy is planned or occurs during treatment.
Breastfeeding while on ATZ 50 mg Tablet is not recommended due to potential risks to the infant.
Avoid alcohol consumption as it may stress the liver when combined with Azathioprine.
Regular blood tests are essential to monitor liver function and blood cell counts during treatment with ATZ 50 mg Tablet.
Patients should avoid live vaccines while on ATZ 50 mg Tablet due to compromised immune function.
1. How long does it take for Azathioprine to work?
The effects of Azathioprine can take between six weeks to six months to become fully apparent, especially in conditions like Crohn's disease or rheumatoid arthritis.
2. Can I get a tattoo while taking ATZ 50 mg Tablet?
Getting a tattoo is generally discouraged while on ATZ 50 mg Tablet due to an increased risk of skin infections and slower healing.
3. Does it cause hair loss?
While complete hair loss is rare, some individuals may notice thinning hair, which typically stabilizes over time.
4. Why does my doctor check my blood every week?
Blood tests are conducted weekly initially to ensure adequate white blood cell production and monitor liver health.
5. Can I take it if I want to have a baby?
Both men and women should discuss family planning with their healthcare provider, as careful monitoring is required during pregnancy.
6. Does it interact with painkillers?
Paracetamol is generally safe; however, consult your doctor before using high-dose NSAIDs like Ibuprofen over extended periods.
7. Is Azathioprine a form of chemotherapy?
Although Azathioprine belongs to a class used in chemotherapy, the doses prescribed for autoimmune diseases are significantly lower than those used for cancer treatment.
Directions for Use
Use only as prescribed by your physician.
Storage and Disposal
Please refer to the product label for storage information.
SKU
155242
Country of Manufacture
India
Manufacturer Address
Intas Pharmaceuticals Ltd.
Return/Buy Back policy
Non-returnable
Prescription Required
Yes
Storage
Please refer to the product label for storage information.
Seller
Kogland Commerce Pvt Ltd (TN)
ATZ 50 mg Tablet is a prescription-only cytotoxic immunosuppressant that plays a crucial role in long-term immune modulation. Composed primarily of Azathioprine, ATZ 50 mg Tablet serves as a prodrug, which means it is converted within the body into its active metabolites. This transformation is essential for its therapeutic effects. Each ATZ 50 mg Tablet contains Azathioprine, which functions as a purine antimetabolite. Upon ingestion, ATZ 50 mg Tablet is metabolized into 6-mercaptopurine (6-MP) and subsequently into thio-guanine nucleotides. These active compounds interfere with the synthesis of DNA and RNA in rapidly dividing cells, particularly T and B lymphocytes. By disrupting the genetic blueprints of these immune cells, ATZ 50 mg Tablet effectively reduces the immune response that could otherwise attack a transplanted organ or the body's own healthy cells. The primary purpose of ATZ 50 mg Tablet lies in its ability to prevent organ rejection in transplant patients and to manage autoimmune disorders. It is categorized under immunosuppressants, making it a vital component in the treatment of conditions such as severe rheumatoid arthritis, ulcerative colitis, Crohn's disease, and autoimmune hepatitis. The therapeutic category of ATZ 50 mg Tablet highlights its importance in managing complex immune-mediated conditions, ensuring that patients receive effective treatment while minimizing the risk of complications associated with their underlying diseases. Overall, ATZ 50 mg Tablet is an essential medication for individuals requiring long-term immune suppression, providing both safety and efficacy in its use.
Uses & Benefits
ATZ 50 mg Tablet effectively prevents organ rejection in kidney, heart, and liver transplant patients.
This formulation is indicated for severe rheumatoid arthritis that has not responded to other treatments.
ATZ 50 mg Tablet is beneficial in managing chronic inflammatory conditions like ulcerative colitis and Crohn's disease.
It offers a steroid-sparing effect, allowing patients to reduce corticosteroid doses and avoid long-term side effects.
ATZ 50 mg Tablet helps protect vital organs from damage caused by chronic inflammation.
This medication has an established safety profile due to decades of clinical use.
ATZ 50 mg Tablet can lead to long periods of disease remission for patients with autoimmune disorders.
It serves as a secondary line of defense for patients who have failed first-line therapies.
ATZ 50 mg Tablet is essential for preventing complications associated with mineral deficiencies in patients undergoing treatment.
This therapy is particularly useful for patients requiring lifetime management of their conditions.
ATZ 50 mg Tablet can significantly improve the quality of life for individuals with chronic immune-mediated diseases.
The medication's ability to selectively target pathways involved in lymphocyte proliferation makes it a valuable treatment option.
How ATZ 50 mg Tablet works
ATZ 50 mg Tablet functions as an immunosuppressant that reduces the action of the body's immune system. This action prevents the rejection of transplanted organs and blocks certain chemical messengers responsible for inflammation associated with joint diseases.
By inhibiting lymphocyte proliferation, ATZ 50 mg Tablet dampens the overactive immune response.
The active metabolites of Azathioprine interfere with DNA and RNA synthesis in immune cells.
ATZ 50 mg Tablet selectively targets T and B lymphocytes, which are crucial in mediating immune responses.
This mechanism helps maintain a balance in immune function without completely shutting down the body's defenses.
ATZ 50 mg Tablet is particularly effective in managing autoimmune disorders by modulating immune activity.
How to use ATZ 50 mg Tablet
ATZ 50 mg Tablet should be taken once or twice daily as prescribed by your healthcare provider.
Swallow the tablet whole; do not crush or break it to avoid exposure to cytotoxic substances.
It is recommended to take ATZ 50 mg Tablet after meals to minimize nausea and stomach upset.
Consistency is key; take ATZ 50 mg Tablet at the same time every day to maintain stable drug levels in the body.
For transplant patients, the initial dose typically ranges from 3mg to 5mg per kg of body weight daily, adjusted based on blood test results.
For autoimmune conditions, dosing often starts at 1mg to 3mg per kg of body weight.
The maintenance dose for most adults usually equates to between 50mg to 150mg daily.
Consult your doctor for any necessary dose adjustments based on your individual response and lab results.
Lifestyle Advice
Maintain a balanced diet rich in vitamins and minerals to support overall health while taking ATZ 50 mg Tablet.
Avoid excessive sun exposure; use sunscreen and protective clothing when outdoors to prevent skin damage.
Stay hydrated and maintain regular physical activity as tolerated to enhance well-being during treatment.
Monitor for signs of infection and report any symptoms promptly to your healthcare provider.
Adhere strictly to scheduled blood tests to ensure safe monitoring of your health status while on ATZ 50 mg Tablet.
Side Effects
Side Effects
Common side effects include nausea and vomiting, especially during the initial weeks of treatment.
Loss of appetite may occur as a side effect of ATZ 50 mg Tablet.
Increased sensitivity to sunlight can lead to sunburn; protective measures are advised.
Some patients may experience mild hair thinning while on ATZ 50 mg Tablet.
Uncommon side effects may include gastrointestinal discomfort such as diarrhea or stomach pain.
Joint pain or muscle aches can occur occasionally during treatment with ATZ 50 mg Tablet.
Mouth ulcers may develop as a side effect; consult your doctor if they persist.
Serious side effects requiring immediate medical attention include bone marrow suppression, indicated by unusual bruising or extreme fatigue.
Signs of infection such as fever or persistent cough should be reported to a healthcare provider promptly.
Liver damage symptoms like jaundice or dark urine necessitate urgent medical evaluation.
Precautions and Warnings
Precautions & Warnings
ATZ 50 mg Tablet should not be used by individuals with known hypersensitivity to Azathioprine or its components.
Caution is advised for patients with kidney or liver disease; dose adjustments may be necessary.
Pregnant women should avoid using ATZ 50 mg Tablet due to potential fetal harm; consult your doctor if pregnancy is planned or occurs during treatment.
Breastfeeding while on ATZ 50 mg Tablet is not recommended due to potential risks to the infant.
Avoid alcohol consumption as it may stress the liver when combined with Azathioprine.
Regular blood tests are essential to monitor liver function and blood cell counts during treatment with ATZ 50 mg Tablet.
Patients should avoid live vaccines while on ATZ 50 mg Tablet due to compromised immune function.
1. How long does it take for Azathioprine to work?
The effects of Azathioprine can take between six weeks to six months to become fully apparent, especially in conditions like Crohn's disease or rheumatoid arthritis.
2. Can I get a tattoo while taking ATZ 50 mg Tablet?
Getting a tattoo is generally discouraged while on ATZ 50 mg Tablet due to an increased risk of skin infections and slower healing.
3. Does it cause hair loss?
While complete hair loss is rare, some individuals may notice thinning hair, which typically stabilizes over time.
4. Why does my doctor check my blood every week?
Blood tests are conducted weekly initially to ensure adequate white blood cell production and monitor liver health.
5. Can I take it if I want to have a baby?
Both men and women should discuss family planning with their healthcare provider, as careful monitoring is required during pregnancy.
6. Does it interact with painkillers?
Paracetamol is generally safe; however, consult your doctor before using high-dose NSAIDs like Ibuprofen over extended periods.
7. Is Azathioprine a form of chemotherapy?
Although Azathioprine belongs to a class used in chemotherapy, the doses prescribed for autoimmune diseases are significantly lower than those used for cancer treatment.
Directions for Use
Use only as prescribed by your physician.
Storage and Disposal
Please refer to the product label for storage information.
SKU
155242
Country of Manufacture
India
Manufacturer Address
Intas Pharmaceuticals Ltd.
Return/Buy Back policy
Non-returnable
Prescription Required
Yes
Storage
Please refer to the product label for storage information.
Seller
Kogland Commerce Pvt Ltd (TN)
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